AbbVie Principal Research Scientist, DMPK in Worcester, Massachusetts
The DMPK Department at AbbVie Bioresearch Center in Worcester, MA, supports discovery teams focused on finding novel therapeutic agents for the treatment of immunological diseases. In addition the Ligand Binding Assay group provides biomarker support for Immunology and has global responsibilities in providing non-GLP PK and ADA methods and sample analysis for biologics projects across all therapeutic areas at AbbVie. The Senior Principal Scientist will be responsible for PK, ADA or BM method development. In addition he/she will represent DMPK-BA on teams to provide guidance on bio analytical issues, ensure alignment and manage timelines.
The successful candidate will work with team of dedicated scientists responsible for developing methods for preclinical PK and ADA assessment. Developing protocols for exposure measurement of biologics from various biological matrixes e.g. tumor or brain. Responsibilities will also include developing new assays for bispecifics and antibody-drug conjugates, as well as evaluating and recommending new bio analytical platforms to accelerate bio analysis of projects from early discovery to development. The candidate is expected to lead evaluation of bio analytical platforms to assess intactness of protein therapeutics in vitro and in vivo in various matrices.
Basic: * BS, MS, or PhD in the bioanalytical field with 16 (BS), 14 (MS), or 8 (Ph.D) years of experience in the pharmaceutical industry * Experience in developing PK and ADA assays as well as biomarker methods * Experience in supervising scientists at all levels in developing and troubleshooting bioanalytical methods. * Excellent oral & written communication skills * Proven track record in scientific excellence, * Experience in supporting drug discovery and development projects, including the ability to: * work as part of a multidisciplinary team, actively participate in- and guide discussions, negotiate priorities * proactively identify issues and bottlenecks, propose solutions, * Develop Biomarker, PK and ADA assays on multiple platforms, propose platform conversion, multiplexing etc. as needed * identify and troubleshoot issues with existing methods * understand process optimization to support automation and high throughput methodologies The ideal candidate will also have: * Excellent interpersonal, leadership & organizational skills * Collaborative spirit to work with colleagues across sites and across disciplines. * Experience in managing timelines, providing input on task prioritization and resource utilization * Experience with antibody-drug conjugates or bispecifics is a must. * Direct experience with Biacore and Gyros technology is a plus * Protein biochemistry background with protein characterization is an advantage
Key Leadership Competencies: * Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance. * Learns fast, grasps the "essence" and can change course quickly where indicated. * Raises the bar and is never satisfied with the status quo. * Creates a learning environment, open to suggestions and experimentation for improvement. * Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Job Classification: Experienced
Job: RESEARCH AND DEVELOPMENT
Primary Location: USA-Massachusetts-Worcester
Organization: Research & Development
Travel: Yes, 5 % of the Time
Req ID: 1705727
Equal Opportunity Employer Minorities/Women/Veterans/Disabled